In vitro platelet signal transduction investigations related to hemostasis and thrombosis
using knock out mice as model systems
In vivo evaluation of the physiological significance of signal transduction pathway
information obtained from invitro studies
Evalution of ligand receptor and signal transduction requirements for stable thrombus
formation in vivo in arteries and veins
Characterization of outside-in signaling mediated by the individual subunits of the
major platelet integrin alphallb/beta3
Development of a model system for the reproducubile induction of venous thromboembolism
(VTE) under quasi physiological conditions for the subsequent evaluation of ligand
receptor and signal transduction requirements for VTE.