Judith A. Cole, Ph.D.

Judith A. Cole, Ph.D.

Associate Professor

Phone
901.678.1363
Fax
901.678.4457
Office
Life Sciences 417, Memphis, TN 38152
Office Hours
By Appointment

About Dr. Cole

Dr. Cole joined the Department in 2003. She teaches BIOL 4480/6480 Cellular and Molecular Pharmacology. BIOL7140/8140 Receptors and Signaling, and BIOL7000/8000 Introduction to Graduate Studies. She began her research career as a comparative endocrinologist, studying the regulation of calcium and phosphate homeostasis in European starlings. In her post-doctoral work, she became interested in the regulation of parathyroid hormone (PTH) receptors and PTH-activated signaling pathways in kidney and bone. At the University of Memphis, Dr. Cole has continued her work on PTH signaling and has also collaborated with colleagues studying the regulation of cell signaling at host-parasite interfaces as well as the role of the epidermal growth factor (EGF) receptor and its ligands in regulating epithelial cell function. Dr. Cole is a member of the American Society for Bone and Mineral Research, American Society for Pharmacology and Experimental Therapeutics, and the American Society for Cell Biology.

Research Interests

  • Cross-talk between G protein-coupled receptors and receptor tyrosine kinases
  • Parathyroid receptor signaling (PTH) in bone and kidney, including biased agonism and its role in the regulation of bone cell function
  • PTH and epidermal growth factor (EGF) regulation of epithelial function
  • Control of cell signaling at host-parasite interfaces

Education

B.S. Zoology, University of Rhode Island; Ph.D. Physiology, University of Connecticut; Post-Doctoral Fellow Pharmacology, University of Missouri School of Medicine

Recent Publications

  • Campion CM, Leon Carrion S, Mamidanna G, Sutter CH, Sutter TR, Cole JA. Role of EGF receptor ligands in TCDD-induced EGFR down-regulation and cellular proliferation. Chemico-Biological Interactions 253:38-47, 2016.

  • Fisher BS, Estraño CE, Cole JA (2013) Modeling Long-Term Host Cell-Giardia lamblia Interactions in an In Vitro Co-Culture System. PLoS ONE 8(12): e81104, 2013.

  • Cooper JO, Bumgardner JD, Cole JA, Smith RA, and Haggard WO (2014). Co-cultured tissue-specific scaffolds for tendon/bone interface engineering. J Tissue Eng 2014 5:1-10.

  • Poole NM, Mamidanna G, Smith RA, Coons LB, and Cole JA. Prostaglandin E2 in tick saliva regulates macrophage cell migration and cytokine profile. Parasites & Vectors, 2013, 6: 261.

  • Poole, NM, Nyindodo-Ogari L, Kramer C, Coons LB and Cole JA. Effects of tick saliva on the migratory and invasive activity of Saos-2osteosarcoma and MDA-MB-231 breast cancer cells. Effects of tick saliva on the migratory and invasive activity of Saos-2. Ticks Tick Borne-Dis 4:120-127, 2013.

  • McCanless JD, Jennings LK, Bumgardner JD, Cole JA, Haggard WO. Hematoma-inspired alginate/platelet releasate/CaPO(4) composite: initiation of the inflammatory-mediated response associated with fracture repair in vitro and ex vivo injection delivery. J Mater Sci Mater Med. 23(8):1971-81, 2012.

  • McCanless JD, Jennings LK, Cole JA, Bumgardner JD, Haggard WO Induction of the early inflammatory-mediated cellular responses of fracture healing in vitro using platelet releasate-containing alginate/CaPO4 biomaterials for early osteoarthritis prevention. . J Biomed Mater Res A. 100(5):1107-14, 2012.

  • Sabri F, Cole JA, Scarbrough MC and Leventis N. Investigation of polyurea-crosslinked silica aerogels as a neuronal scaffold: a pilot study.. PLoS ONE 7:e33232, 2012

  • McCanless JD, Jennings LK, Cole JA, Bumgardner JD, Haggard WO. In vitro differentiation and biocompatibility of mesenchymal stem cells on a novel platelet releasate-containing injectable composite. J Biomed Mater Res A. J Biomed Mater Res A. 100:220-229, 2012

  • McCanless JD, Cole JA, Slack SM, Bumgardner JD, Zamora PO, Haggard WO. Modeling nucleus pulposus regeneration in vitro: mesenchymal stem cells, aginate beads, hypoxia, BMP2, and synthetic peptide B2A. Spine 36:2275-2285, 2011.