1989 B.S. Biology, University of Houston
1996 Ph.D. Biochemistry, University of Houston
1996-2001 Post-Doctoral Associate, Dept. of Developmental Neurobiology, St. Jude Children's
Research Hospital, Memphis
2001-2006 Assistant Professor, Dept. of Neurology, University of Tennessee Health Science Center
2001-present Adjunct Assistant Professor, Dept. of Anatomy and Neurobiology, University of Tennessee Health Science Center
2001-present Associate Professor, Dept. of Biology, University of Memphis
2001-present Adjunct Associate Professor, Dept. of Neurology, University of Tennessee Health Science Center
My lab is investigating the molecular and cellular mechanisms of neuronal migration and dendrite maturation during mammalian brain development. We are currently characterizing the function of a novel GTPase activating protein, Disabled 2 Interacting Protein (Dab2IP), during brain development using a mouse knock-out model and a variety of biochemical, cellular, morphological and behavioral approaches.
My lab is investigating the physiological and pathophysiological role of amyloid precursor protein (APP) and its family members, amyloid precursor like proteins 1 and 2, using mouse knock-out models. Mutations in APP have been linked to early-onset Alzheimer's Disease, but very little is known about its physiological role in the brain. Currently, we are using genomic, proteomic, and cell-based approaches to identify gene and protein networks that are associated with APP family proteins.
My lab is developing text-mining approaches to automatically extract gene function information from the biomedical literature abstracts to assist in interpretation of high-throughput genomic studies.