Using the theory of role dynamics, we develop a model linking nurses' perceptions of an information system's compatibility with their values to work stress and burnout. We surveyed registered nurses and tested the research hypotheses via the partial least squares approach to structural equation modeling. Our results demonstrate a linkage between nurses' perceptions of IS compatibility with values, role conflict, and burnout, thus contributing to our understanding of the ways in which IS usage has the potential to impact users, especially in mandatory usage environments. Implications and study limitations are also discussed.