Research Interests

  • Autotaxin (ATX) is a phosphodiesterase that generates lysophosphatidic acid from lysophosphatidylcholine. Efforts are ongoing to understand the regulation of ATX activity by both endogenous and synthetic modulators. ATX inhibitors may be novel therapeutics against cardiovascular disease and cancer.

  • Sphingosine kinase (SK) mediates a phosphoryl group transfer from ATP to sphingosine that generates ADP and sphingosine 1-phosphate. Efforts are ongoing to improve the analysis of SK activity to better identify modulators. SK inhibitors may be novel therapeutics against fibrosis and autoimmune diseases.

  • Diacylglycerol Kinase (DGK) mediates a phosphoryl group transfer from ATP to diacylglycerol that generates ADP and phosphatidic acid. Efforts are ongoing to improve the analysis of DGK activity to better identify modulators. DGK inhibitors may be novel antibiotics.