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Evaluation of a Synthetic Vertebral Body Model for Rapid and Reliable Testing of INJECTABLE BONE CEMENTS for Balloon Kyphoplasty

Evaluation of a Synthetic Vertebral Body Model for Rapid and Reliable Testing of INJECTABLE BONE CEMENTS for Balloon Kyphoplasty

Given by: Dr. Gladius Lewis
Department of Mechanical Engineering, The University of Memphis

Wednesday, April 2, 2008

3:00-4:00pm in Manning Hall room 201

Refreshments will be served beginning at 2:30pm in Manning Hall room 222

Abstract:

Compression fractures of vertebral bodies (VBs) are a common consequence of severe osteoporosis. Balloon kyphoplasty (BKP) has emerged as one of the modalities of choice for the treatment of these fractures. BK involves using a bone tamp to create a void in the fractured VB and, then, filling that void with a bolus of an injectable bone cement. Each of the cement types that are in current use has many drawbacks. Thus, there is scope for improving these cements and/or developing a new generation of them. In this research work, in vitro evaluation of the experimental cement is an important step. This evaluation may be carried out using cadaveric VBs, VBs from animal model spines, or a synthetic VB model.

In this seminar presentation, results using a synthetic VB model would be presented.

Specifically, the model was a cube (26 mm sides) of low-density open-cell polyurethane foam with a centrally-located through-thickness cylindrical hole completely filled with a bolus of a cement. Two BKP injectable bone cements with very different chemistries (a high-viscosity acrylic bone cement and a calcium phosphate bone substitute) were used. In mechanical tests, the model was immersed in phosphate buffered saline, at 37°C; the frequency was 3 Hz; and the maximum load was either 1150 N or 2300 N. Clear demarcation was seen in the qualitative results (fracture patterns) and the quantitative results (Kaplan-Meier survival analysis of the number of cycles to failure) obtained with the two materials tested. Thus, the use of this model for rapid and reliable in vitro screening of BKP injectable bone cements was considered both valid and appropriate (that is, cl

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