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Multiscale Mechanical Characterization of Liver Tissue

Esra Roan

Department of Biomedical Engineering, University of Memphis, TN 38152

September 24, 2008, 4:00pm, Manning Hall 201

Refreshments served at 3:30pm, Manning Hall 222

In this presentation, introduction to mechanical of soft tissue characterization will be provided via a unique application: liver.  Experimental and computational aspects of liver mechanics will be presented to show the link between mechanical response and clinical applications.

 Liver is the tissue of interest, because liver diseases affect many people and result in cirrhosis, which is a life-threatening condition.  Early stage of the liver disease is marked by increasing deposition of extracellular matrix (ECM) proteins that change the micro-structure of the liver drastically.  Recent advances in drug treatments reversing disease increased the emphasis on early detection and frequent monitoring of progression.  

Current gold standard of the liver disease diagnosis is the ``liver biopsy'' which is a subjective and painful procedure.  Therefore, alternative noninvasive diagnostic tools mapping mechanical properties of the liver tissue are becoming popular.   In addition, link between increased ECM of the liver and the increased elastic modulus is widely accepted via in vivo measurement using transient elastography or indentation.

 Besides prevalence of liver diseases and the established correlation between liver diseases and stiffness, liver has a unique hierarchical architecture allowing the use of averaging techniques.   

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Last Updated: 10/11/12