Department of Biomedical Engineering, University of Memphis, TN 38152
September 24, 2008, 4:00pm, Manning Hall 201
Refreshments served at 3:30pm, Manning Hall 222
In this presentation, introduction to mechanical of soft tissue characterization will
be provided via a unique application: liver. Experimental and computational aspects
of liver mechanics will be presented to show the link between mechanical response
and clinical applications.
Liver is the tissue of interest, because liver diseases affect many people and result
in cirrhosis, which is a life-threatening condition. Early stage of the liver disease
is marked by increasing deposition of extracellular matrix (ECM) proteins that change
the micro-structure of the liver drastically. Recent advances in drug treatments
reversing disease increased the emphasis on early detection and frequent monitoring
Current gold standard of the liver disease diagnosis is the ``liver biopsy'' which
is a subjective and painful procedure. Therefore, alternative noninvasive diagnostic
tools mapping mechanical properties of the liver tissue are becoming popular. In
addition, link between increased ECM of the liver and the increased elastic modulus
is widely accepted via in vivo measurement using transient elastography or indentation.
Besides prevalence of liver diseases and the established correlation between liver
diseases and stiffness, liver has a unique hierarchical architecture allowing the
use of averaging techniques.