Mark LeDoux, M.D., Ph.D., FANA

Affiliate Research Professor

Psychology 450
Office Hours
Contact for Appointment
Mark LeDoux

Dr. LeDoux is a clinician-scientist. He maintains an active basic science lab, and busy clinical practice that includes deep brain stimulation, injections of botulinum toxins, and clinical trials for dystonia, Parkinson disease, spasticity, tardive dyskinesia, and Huntington disease. Dr. LeDoux is internationally-recognized as a leader in patient care and research related to Parkinson disease, dystonia, and other movement disorders. He is a member of the Dystonia Coalition and Parkinson Study Group. Although his lab interests have been focused on neurogenetics and the pathobiology of dystonia, he has used a wide variety of experimental approaches to also study the anatomy and computational organization of motor and autonomic systems, mechanisms of cell death in Parkinson disease, and cell-cycle control in the central nervous system. At present, he serves on the Editorial Boards of Neurology and Tremor and Other Hyperkinetic Movements. Dr. LeDoux has been the author or co-author of more than 150 scientific articles and book chapters, and three books including Movement Disorders: Genetics and Models (Elsevier, ISBN: 9780124051959, 1259 pages). When not in clinic or the lab, Dr. LeDoux enjoys mountaineering, fly fishing, and trail running with his kids.

Offices and Committees

  • Chairman, Board of Medical Advisors, National Spasmodic Torticollis Association
  • Member, Scientific Advisory Board Spastic Paraplegia Foundation
  • Director, Huntington Disease Center of Excellence

Honors and Awards

  • Joel Fletcher Outstanding Graduate Award (Chemistry, summa cum laude)
  • Dystonia Doctor of Excellence Award from the Dystonia Medical Research Foundation
  • Elected Fellow American Neurological Association
  • Best Doctors in America®
  • Castle Connolly Medical Ltd, America's Top Doctors®
  • University of Tennessee Postdoctoral Research Trainee Distinguished Mentor Award
  • British Medical Association Medical Book Awards 2015 – Highly Commended


  • Ph.D. University of Alabama at Birmingham
  • M.D. Louisiana State University New Orleans

Research Interests

  • Genetics and Molecular Neurobiology of Dystonia
  • Pharmaceutical and Neurosurgical Treatment of Movement Disorders
  • Cell Cycle Control in the Central Nervous System
  • Neural Circuitry of Movement

Recent Publications

Please visit the Google Scholar website for up to date publication information.