About Dr. Truc Chi Pham
Education
2005 Ph.D. Chemistry University of Memphis
2003 M. S. Chemistry University of Memphis
2001 B.S Summa Cum Laude Physics University of Memphis
2000 B.S Summa Cum Laude Chemistry University of Memphis
1990 B.S. Animal Husbandry Cantho University
Admitted
2006 - Present Research Scientist Chemistry University of Memphis
2004 - Present Vietnamese Tester Foreign Languages and Literatures University of Memphis
2005 - 2006 Post-doc Chemistry University of Memphis
Experience
Research and Scholarly Activities
Research Interests
Protein structure, function and modeling
Rational ligand design and activity screening
Mass and NMR spectrometry
Publications
Fells JI, Lee SC, Norman DD, Tsukahara R, Kirby JR, Nelson S, Seibel W, Papoian R, Patil R, Miller DD, Parrill AL, Pham TC, Baker DL, Bittman R, Tigyi G. Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif. FEBS Journal 2014, 281: 1017–1028
Young JK, Clayton BT, Kikonyogo A, Pham TC, Parrill AL. Structural Characterization of an LPA1 Second Extracellular Loop Mimetic with a Self-AssemblingCoiled-Coil Folding Constraint. Int J Mol Sci. 2013, 14(2):2788-807
Baker DL, Pham TC, Sparks MA. Structure and catalytic function of sphingosine kinases: Analysis by site-directed mutagenesis and enzyme kinetics. Biochim Biophys Acta. 2013, 1831(1):139-46
Singh WM, Baine T, Kudo S, Tian S, Ma XA, Zhou H, DeYonker NJ, Pham TC, Bollinger JC, Baker DL, Yan B, Webster CE, Zhao X. 2. Electrocatalytic and photocatalytic hydrogen production in aqueous solution by a molecular cobalt complex. Angew Chem Int Ed Engl., 2012, 51(24):5941-4
Parrill AL, Wanjala IW, Pham TC, Baker DL. "Computational Identification and Experimental Characterization of Substrate Binding Determinants of Nucleotide Pyrophosphatase/Phosphodiesterase 7" BMC Biochem. 2011, 12(1): 65
Gupte, Renuka; Patil, Renukadevi; Liu, Jianxiong; Wang, Yaohong; Lee, Sue C.; Fujiwara, Yuko; Fells, James; Bolen, Alyssa L.; Emmons-Thompson, Karin; Yates, C. Ryan; Siddam, Anjaih; Panupinthu, Nattapon; Pham, Truc-Chi T.; Baker, Daniel L.; Parrill, Abby L.; Mills, Gordon B.; Tigyi, Gabor; Miller, Duane D., "Benzyl and Naphthalene Methylphosphonic Acid Inhibitors of Autotaxin with Anti-invasive and Anti-metastatic Activity" ChemMedChem. 2011, 6(5): 922-935.
Gupte R, Siddam A, Lu Y, Li W, Fujiwara Y, Panupinthu N, Pham TC, Baker DL, Parrill AL, Gotoh M, Murakami-Murofushi K, Kobayashi S, Mills GB, Tigyi G, Miller DD. "Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid" Bioorg Med Chem Lett. 2010, 20(24):7525-8
Valentine WJ, Kiss GN, Liu J, E S, Gotoh M, Murakami-Murofushi K, Pham TC, Baker DL, Parrill AL, Lu X, Sun C, Bittman R, Pyne NJ, Tigyi G. "(S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity." Cell Signal. 2010, 22(10):1543-53.
North EJ, Howard AL, Wanjala IW, Pham TC, Baker DL, Parrill AL. "Pharmacophore development and application toward the identification of novel, small-molecule autotaxin inhibitors." J Med Chem. 2010, 53(8):3095-105.
Hoeglund AB, Howard AL, Wanjala IW, Pham TC, Parrill AL, Baker DL. "Characterization of non-lipid autotaxin inhibitors." Bioorg Med Chem. 2010, 18(2):769-76.
Pham TC, Fells JI, Sr., Osborne DA, North EJ, Naor MM, Parrill AL. "Molecular Recognition in the Sphingosine 1-Phosphate Receptor Family." J. Mol. Graphics Modell. 2008, 26(8):1189-201
Parrill, A.L.; Echols, U.*; Nguyen, T.*; Pham, T.C.T.; Hoeglund, A.; Baker, D. L. "Virtual Screening Approaches for the Identification of Non-Lipid Autotaxin Inhibitors", Bioorg. Med. Chem., 2008, 16(4), 1784-1795.
Pham TC, Kriwacki RW, Parrill AL. "Peptide Design and Structural Characterization of a GPCR Loop Mimetic." Biopolymers. 2007, 86(4):298-310 (highlighted in front page).
Inagaki Y, Pham TT, Fujiwara Y, Kohno T, Osborne DA, Igarashi Y, Tigyi G, Parrill AL. "Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors." Biochem J. 2005, 389(Pt 1):187-95
Holdsworth G, Osborne DA, Pham TT, Fells JI**, Hutchinson G, Milligan G, Parrill AL. "A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor." BMC Biochem. 2004; 5:12.