Faculty Picture

Truc Chi Pham

Research Scientist

3744 Walker Ave., 427 Smith Chemistry, Memphis, TN 38152
Office Hours
7:00a.m. - 3:30p.m., Monday through Friday

About Dr. Truc Chi Pham


2005    Ph.D.   Chemistry     University of Memphis

2003    M. S.     Chemistry    University of Memphis

2001    B.S    Summa Cum Laude      Physics      University of Memphis

2000    B.S    Summa Cum Laude      Chemistry     University of Memphis

1990    B.S.   Animal Husbandry      Cantho University


2006 - Present Research Scientist       Chemistry      University of Memphis

2004 - Present Vietnamese Tester     Foreign Languages and Literatures    University of Memphis

2005 -  2006   Post-doc     Chemistry     University of Memphis


Research and Scholarly Activities

Research Interests

Protein structure, function and modeling

Rational ligand design and activity screening

Mass and NMR spectrometry


Fells JI, Lee SC, Norman DD, Tsukahara R, Kirby JR, Nelson S, Seibel W, Papoian R, Patil R, Miller DD, Parrill AL, Pham TC, Baker DL, Bittman R, Tigyi G. Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif. FEBS Journal 2014, 281: 1017–1028

Young JK, Clayton BT, Kikonyogo A, Pham TC, Parrill AL. Structural Characterization of an LPA1 Second Extracellular Loop Mimetic with a Self-AssemblingCoiled-Coil Folding Constraint. Int J Mol Sci. 2013, 14(2):2788-807

Baker DL, Pham TC, Sparks MA. Structure and catalytic function of sphingosine kinases: Analysis by site-directed mutagenesis and enzyme kinetics. Biochim Biophys Acta. 2013, 1831(1):139-46

Singh WM, Baine T, Kudo S, Tian S, Ma XA, Zhou H, DeYonker NJ, Pham TC, Bollinger JC, Baker DL, Yan B, Webster CE, Zhao X. 2. Electrocatalytic and photocatalytic hydrogen production in aqueous solution by a molecular cobalt complex. Angew Chem Int Ed Engl., 2012, 51(24):5941-4

Parrill AL, Wanjala IW, Pham TC, Baker DL. "Computational Identification and Experimental Characterization of Substrate Binding Determinants of Nucleotide Pyrophosphatase/Phosphodiesterase 7" BMC Biochem. 2011, 12(1): 65

Gupte, Renuka; Patil, Renukadevi; Liu, Jianxiong; Wang, Yaohong; Lee, Sue C.; Fujiwara, Yuko; Fells, James; Bolen, Alyssa L.; Emmons-Thompson, Karin; Yates, C. Ryan; Siddam, Anjaih; Panupinthu, Nattapon; Pham, Truc-Chi T.; Baker, Daniel L.; Parrill, Abby L.; Mills, Gordon B.; Tigyi, Gabor; Miller, Duane D., "Benzyl and Naphthalene Methylphosphonic Acid Inhibitors of Autotaxin with Anti-invasive and Anti-metastatic Activity" ChemMedChem. 2011, 6(5): 922-935.

Gupte R, Siddam A, Lu Y, Li W, Fujiwara Y, Panupinthu N, Pham TC, Baker DL, Parrill AL, Gotoh M, Murakami-Murofushi K, Kobayashi S, Mills GB, Tigyi G, Miller DD. "Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid" Bioorg Med Chem Lett. 2010, 20(24):7525-8

Valentine WJ, Kiss GN, Liu J, E S, Gotoh M, Murakami-Murofushi K, Pham TC, Baker DL, Parrill AL, Lu X, Sun C, Bittman R, Pyne NJ, Tigyi G. "(S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity." Cell Signal. 2010, 22(10):1543-53.

North EJ, Howard AL, Wanjala IW, Pham TC, Baker DL, Parrill AL. "Pharmacophore development and application toward the identification of novel, small-molecule autotaxin inhibitors." J Med Chem. 2010, 53(8):3095-105.

Hoeglund AB, Howard AL, Wanjala IW, Pham TC, Parrill AL, Baker DL. "Characterization of non-lipid autotaxin inhibitors." Bioorg Med Chem. 2010, 18(2):769-76.

Pham TC, Fells JI, Sr., Osborne DA, North EJ, Naor MM, Parrill AL. "Molecular Recognition in the Sphingosine 1-Phosphate Receptor Family." J. Mol. Graphics Modell. 2008, 26(8):1189-201

Parrill, A.L.; Echols, U.*; Nguyen, T.*; Pham, T.C.T.; Hoeglund, A.; Baker, D. L.  "Virtual Screening Approaches for the Identification of Non-Lipid Autotaxin Inhibitors", Bioorg. Med. Chem., 2008, 16(4), 1784-1795.

Pham TC, Kriwacki RW, Parrill AL. "Peptide Design and Structural Characterization of a GPCR Loop Mimetic." Biopolymers. 2007, 86(4):298-310 (highlighted in front page).

Inagaki Y, Pham TT, Fujiwara Y, Kohno T, Osborne DA, Igarashi Y, Tigyi G, Parrill AL. "Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors." Biochem J. 2005, 389(Pt 1):187-95

Holdsworth G, Osborne DA, Pham TT, Fells JI**, Hutchinson G, Milligan G, Parrill AL. "A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor." BMC Biochem. 2004; 5:12.