Charles A. Lessman, Ph.D.

Charles A. Lessman, Ph.D.

Professor

Phone
901.678.2963
Fax
901.678.4457
Office
Life Sciences Room 223, Lab LS 211
Office Hours
By Appointment or when office door is open

About Dr. Lessman

Dr. Charles A. Lessman joined the Faculty in 1988 as an associate professor and in 1993 he was promoted to the rank of professor. Dr. Lessman received his Ph.D. from the Department of Genetics & Cell Biology at the University of Minnesota. He was a Mellon Postdoctoral Fellow in the Department of Population Dynamics, at the Johns Hopkins University. He served as an assistant then associate Professor at St. Francis Xavier University in Nova Scotia, Canada and currently is a Professor in the Department of Biological Sciences at the University of Memphis. He has been a visiting professor at the University of Iowa, the Vanderbilt University and at St. Jude Children's Research Hospital. Dr. Lessman's research focus is on reproductive and developmental biology and he has employed a number of different model organisms but most recently has used zebrafish. He teaches Cell Biology, Developmental Biology, Cell Physiology, Vertebrate Cell Culture and offers Undergraduate and Graduate research projects on zebrafish genetics, reproduction and development.

Research Interests

  • Reproduction in vertebrates, especially time-course of gonad dynamics in individual transparent Casper zebrafish.
  • Effect of Endocrine Disrupting Chemicals (EDCs) on puberty and reproduction of zebrafish.
  • Centrosome and microtubule dynamics in the oocyte-egg transition.
  • Identification, screening and mapping of motility mutants in zebrafish.

Education

B.A. Psychology, minor: chemistry, University of Minnesota; M.S. Zoology, University of Minnesota Dept. of Zoology; Ph.D. Genetics-Cell Biology, Minor: biochemistry, University of Minnesota; Post-Doctoral Fellow Johns Hopkins University, Dept. of Population Dynamics, Division of Reproductive Biology, Baltimore, Md.

Recent Publications

  • Charles A. Lessman (2014) "The protein phosphatase inhibitor, okadaic acid, elicits several components of zebrafish (Danio rerio) oocyte maturation in vitro." In: Zebrafish: Topics in Reproduction, Toxicology and Development. Eds: Lessman, C. A. and Carver, E. A. Nova Science Publishers, Inc., N.Y. ISBN: 978-1-63117-569-5 (eBook); 978-1-63117-558-9 (hardcopy). Chapter 3, p. 39-63.
  • Charles A. Lessman (2014) "Fecundity and spawning frequency in wild-type zebrafish mated pairs: A long-term, longitudinal study." In: Zebrafish: Topics in Reproduction, Toxicology and Development. Eds: Lessman, C. A. and Carver, E. A. Nova Science Publishers, Inc., N.Y. ISBN: 978-1-63117-569-5 (eBook); 978-1-63117-558-9 (hardcopy). Chapter 6, p. 123-131.
  • Ethan A. Carver, Michael R. Taylor, Linda Sircy, and Charles A. Lessman (2014) "Localization of the sodium-potassium-chloride cotransporter gene (slc12a2) protein products during zebrafish embryogenesis and myogenesis and a screen for additional antibodies to study zebrafish myogenesis." In: Zebrafish: Topics in Reproduction, Toxicology and Development. Eds:. Lessman, C. A. and Carver, E. A Nova Science Publishers, Inc., N.Y. ISBN: 978-1-63117-569-5 (eBook); 978-1-63117-558-9 (hardcopy). Chapter 7, p. 135-154.
  • Ethan A. Carver, Michael R. Taylor, Lauren Milleville, and Charles A. Lessman (2014) "The zebrafish dead elvis (DEL) mutant encodes titinA." In: Zebrafish: Topics in Reproduction, Toxicology and Development. Eds: Lessman, C. A. and Carver, E. A. Nova Science Publishers, Inc., N.Y. ISBN: 978-1-63117-569-5 (eBook); 978-1-63117-558-9 (hardcopy). Chapter 8, p. 155-177.
  • Christopher J. Eden, Bensheng Ju, Mohankumar Murugesan, Timothy Phoenix, Birgit Nimmervoll, Yiai Tong, David W. Ellison, David Finkelstein, Karen Wright, Nidal Boulos, Jason Dapper, Radhika Thiruvenkatam, Charles Lessman, Michael R. Taylor, Richard J. Gilbertson (2014) Orthotopic models of pediatric brain tumors in zebrafish. Oncogene 0, (21 April 2014) Doi:10.1038/onc.2014.107
  • Liu, J. and Lessman, C.A. (2013) Changes in -tubulin protein distribution in zebrafish (Danio rerio) oocytes and the early cleavage-stage embryo. ISRN Developmental Biology vol. 2013, Article ID 920265, 11 pages, 2013. http://dx.doi.org/10.1155/2013/920265
  • Lessman, C. A. (2012) Centrosomes in the zebrafish (Danio rerio): A review including the related basal body. BioMedCentral Cilia 1:9-22. http://www.ciliajournal.com/content/1/1/9
  • Lessman, C. A. (2011) The Developing Zebrafish (Danio rerio): A Vertebrate Model for High-Throughput Screening (HTS) of Chemical Libraries. Birth Defects Research (Part C) 93:268-280. https://umdrive.memphis.edu/cestrano/EstranoLab/index.html
  • Lessman, C. A., Taylor, M.R., Orisme, W. and Carver, E.A. (2010) Use of flatbed transparency scanners in zebrafish research: Versatile and economical adjuncts to traditional imaging tools for the Danio rerio laboratory. Methods in Cell Biology 100: 295-322.
  • Lessman, C.A. (2009) Oocyte maturation: converting the zebrafish oocyte to the fertilizable egg. General and Comparative Endocrinology 161:53-57. http://dx.doi.org/10.1016/j.ygcen.2008.11.004