Omar Skalli, Ph.D.
Professor, Director, Integrated Microscopy Center
Life Sciences 103
- Cytoskeleton, with an emphasis on intermediate filaments and their interaction with
actin filaments. We are especially interested in intermediate filament protein synemin
and its binding to the actin filament bundling protein a-actinin.
- Role of intermediate filaments in the motility of astrocytoma of cells. Astrocytoma
cells express four intermediate filament proteins, including vimentin, nestin, GFAP,
and synemin. We are examining the respective contributions of these proteins to the
motility of astrocytoma cells as well as the mechanisms involved.
- Involvement of intermediate filament proteins, and of synemin in particular, in P13K/Akt
- Functional differences between a-actinin 1 and 4, two a-actinin isoforms differently regulated during brain development and critical for the motility and proliferation of normal and malignant neural cells.