We Protect You in Your Sleep 

by feedback-controlled delivery of drugs during anesthesia 

Dr. Ernő I. Lindner  
R. Eugene Smith Professor of Biomedical Engineering and Professor of Chemistry 
ET 321D 
(901) 678-5641 

Research interests: Development and application of chemical and biosensors.   

M.S. Chemical Engineering, Technical University of Budapest, Hungary, 1971  
C.Sci. Analytical Chemistry, Hungarian Academy of Sciences, 1984 
Ph.D. Analytical Chemistry, Technical University of Budapest, Hungary, 1985 
D.Sci., Analytical Chemistry, Hungarian Academy of Sciences, 1994 
Brief Research Summary and Biosketch: 
Dr. Lindner studied Chemical Engineering at Technical University of Budapest. After graduation, he started to work in the Department of Analytical Chemistry of the same institution. This was only a few years after the pioneering work of his mentor Ernő Pungor, on ion-selective electrodes (ISEs). At that time, it was not clear that the discovery of ISEs will change critical care diagnostics and blood analysis for good. The beginning of his scientific carrier Dr. Lindner focused on studies related the response mechanism of ISEs to improve their performance characteristics, e.g., response time, selectivity, and detection limit. He became a biomedical engineer when he received an opportunity to work in the first NSF Engineering Research Center (ERC) in Biomedical Engineering, the Center for Emerging Cardiovascular Technologies, at Duke University on the in vivo implementation of ISEs. In the frame of this multi-university effort (Duke, UNC Chapel Hill, NC State and Case Western Reserve University) he developed microfabricated chemical sensors for monitoring the chemical markers of induced ischemia. In vivo measurements require reliable biocompatible sensors with superb long-term stability and extended lifetime. In the NSF ERC Dr. Lindner worked on biocompatibility of implanted ion-sensors and developing methods for the determination of the residual lifetime of implanted sensors. In the Department of Biomedical Engineering at the University of Memphis, with his students he focused on the practical applications of chemical sensors. In collaboration with physicians at Le Bonheur Children Hospital, The University Tennessee Health Science Center, and Instrumentation Laboratory he works on chemical sensors with short equilibration time (e.g., K+, Na+, H+, Ca2+) and superb long-term stability using superhydrophobic, inherently conductive polymers as solid contact on sensor platforms prepared by thin-, and thick-film microfabrication technologies. The chemical sensors developed in Dr. Lindner’s laboratory are used for monitoring Na+ concentrations and CO2 levels in the urine of critically ill patients (e.g., diabetic ketoacidosis and septic shock) and a variety of highly hydrophobic drugs, like tricyclic antidepressants and the fast-acting anesthetic drug propofol. To reduce the required sample volume for analysis, most recently he works on the synthesis of reagent-loaded porous polymeric nanocapsules for the measurement of the pH and glucose concentrations in sub-microliter samples, e.g., in the tear fluid of patients with dry eye syndrome.  
Dr. Lindner published one book, 174 peer reviewed journal articles, 25 book chapters, 12 patent disclosures, and gave 270+ conference presentations and invited lectures. His papers received over 9000 citations. Dr. Lindner mentored 29 MS, 13 PhD students. During his stay at the University of Memphis 9 international students, 11 post-doctoral fellows and 3 visiting professors worked in his laboratory. His students received 24 awards for their work in Dr. Lindner’s laboratory and 3 of his PhD students had the opportunity to work abroad (Hungary, Finland) during their graduate studies in collaborating institutions. Dr. Lindner is a IUPAC fellow and regular reviewer for variety of chemical sensing and analytical chemistry related journals.   
Board of Visitors, Willard R. Sparks Eminent Faculty Award, University of Memphis, 2010 
Alumni Association, Distinguished Research Award, Sci., Eng, Math., University of Memphis 2009 
R. Eugene Smith Professor of Biomedical Engineering, University of Memphis, 2007 
Outstanding Faculty Research Award, Herff College of Engineering, 2007 
Ballard Professor of Biomedical Engineering, Herff College of Engineering, 2006 
Award of the Hungarian Academy of Sciences, 1990 
Award of “Best Scientific Paper of the Year, Hungarian Journal of Chemistry, 1989 
Honored Inventor, Hungarian Ministry of Industry, 1986