Making Hip and Knee Replacement Last Forever

by eliminating biologic responses to total joint implants and improving surgical techniques

William M. Mihalko

William M. Mihalko. MD PhD 
Professor & Chair Joint Program in Biomedical Engineering
UTHSC Coleman Building A307
(901) 448-5880

Research interests

Biologic corrosion of implants seems to be an issue within a subset of patients undergoing total hip and knee arthroplasty. We have documented this occurrence through implant retrieval analyses studies and recreated the process in vitro. Synovial fluid analyses and electrochemical potential differences from patient to patient also seem to have an impact on outcomes that I am investigating as well. Working to determine how to eliminate and or identify those at risk are one of the major areas of interest in my laboratory. Other interests include motion analysis research to determine the effects of surgical technique on outcomes after total hip and knee arthroplasty.


 University of Rochester,   Bachelor of Science May 1987 Engineering & Applied Science

 Virginia Commonwealth University, Medical College of Virginia Masters of Science, May 1989 Biomedical Engineering  

 Virginia Commonwealth University, Medical College of Virginia, Doctor of Medicine, May 1993.

 Virginia Commonwealth University Doctor of Philosophy, May 1993 Biomedical Engineering

 Orthopaedic Surgery Internship  Medical College of Virginia Hospital, June 1993-June 1994

 Orthopaedic Surgery Residency  State University of New York at Buffalo, Buffalo, New York, July 1995- June 1999

 Orthopaedic Research Post-Doctoral Fellowship State University of New York at Buffalo, Buffalo General Hospital, June 1994-June 1995.

Orthopaedic Surgery Fellowship in Adult Reconstructive Surgery, Missouri Bone and Joint Center, Barnes Jewish Hospital, St Louis, Missouri, Dr. Leo A. Whiteside, MD Fellowship Director, July 1999- June 2000.

Brief Research Summary and Biosketch

In 2012 I was appointed into the J.R. Hyde endowed chair in Biomedical Engineering and now serve as the chair of the joint graduate program in biomedical engineering at the University of Tennessee Health Science Center.  Here I have fostered collaborative research in my three areas of interest: Retrieval studies of orthopaedic implants, gait studies concerning hip and knee replacement and clinical research. Our retrieval analysis laboratory is a collaborative effort with Drexel, and Clemson University. My clinical research also focuses on biomarkers of aseptic and total joint replacement failures.  

I am the editor of 9 textbooks, on the editorial boards of 4 major orthopaedic journals, A co-editor of one journal, have published over 180 peer reviewed and invited manuscripts and presented over 300 clinical and scientific papers across the globe.  My current H index is 38. I have been a guest lecturer/surgeon on five different continents over the course of my career. Currently, I am a co-investigator on a Major DOD grants, I have been the site PI on a number of sponsored prospective randomized clinical research trials, and have one NIH R34 grant for a clinical trial planning phase from 7/2018-12/2020 as an MPI with the U01 application now under review. 

Brief List of Honors

 Only Orthopaedic Surgeon in the state of Tennessee to be Elected into both The Knee Society and the Hip Society.

Awarded the American Orthopaedic Association American British and Canadian Traveling Fellowship, 2009. Joseph S. Barr Award from ASTM International for outstanding meritorious contributions from a physician, May 2011.

Inducted into the American Institute of Medical and Biological Engineers, March 24, 2014

The Manny Horowitz Award, ASTM International, 2016.

The Senior Achievement Award American Academy of Orthopaedic Surgeons 2017

The Award of Merit ASTM International 2018.

Charles B. Dudley Award, ASTM International, 2020

Named one of the top 50 Leading International Experts in Total Knee Replacement by ExpertScape 2014-2019.

Publications >