Research Publications

The following peer-reviewed manuscripts are a representative sample of the work that has been done within the Center.


Lennon, S., Lackie, T., Miltko, A., Kearns, Z. C., Paquette, M. R., Bloomer, R. J., Wang, A., & van der Merwe, M. (2024). Safety and efficacy of a probiotic cocktail containing P. acidilactici and L. plantarum for gastrointestinal discomfort in endurance runners: Randomized double-blinded crossover clinical trial. Applied Physiology, Nutrition, and Metabolism.

Hellenbrand, J., Bloomer, RJ, van der Merwe, M. (2024) The Effect of Short-Term NAD3® Supplementation on Circulating Adult Stem Cells in Healthy Individuals Aged 40-70 Years. Cureus, 16(3), e55661.

Pence J., Stockton M., Bloomer, RJ. The dietary supplement Cyplexinol® alleviates joint pain in men and women. Journal of Clinical and Translational Research 2023; 9(3): 212-221.

Bloomer, RJ, Pence, J., Davis, A. and Stockton, M. (2023) Weight Loss and Improved Metabolic Health Meas-ures Using a One-Week Active Nutrition Jumpstart Program in Overweight and Obese Men and Women. Health , 15, 640-653.

Bloomer, R.J.; Zhang, Y.; Shirazi, J.Y.; Okegbe, C.; Pence, J.; Martin, K.; Q. Timmcke, J.; LeBaron, T.W. Alpha Hope, via Molecular Hydrogen and Pyrroloquinoline Quinone, Dose-Dependently Increases Nrf2 and PGC-1α Levels in C2C12 Myoblasts. Processes 2023, 11, 2011. https://doi.org/10.3390/pr11072011

Bloomer RJ, Pence JC, Morris R Jr., Stockton M, & Signaigo A. A topical botanical ointment relieves joint pain in men and women with hip and/or knee pain. Journal of Evidence-Based Integrative Medicine.<Jan-Dec;27:2515690X221138824, 2022.

Mondal G, Wang YH, Cathings Z, Butawan M, Bloomer RJ, & Yates CR. Caffeine and Methylliberine: A human pharmacokinetic interaction study.  5(3), 2022.

Bloomer, RJ, Martin, K.R. and Pence, J. Impact of AmaTea on physiological measures and gaming performance in active gamers: a placebo-controlled, double-blind randomized study, Journal of Clinical and Translational Research, 8(2):5, 2022.

Ramanathan C, Lackie T, Williams DH, Simone PS, Zhang Y and Bloomer RJ. Oral Administration of Nicotinamide Mononucleotide Increases Nicotinamide Adenine Dinucleotide Level in an Animal Brain. Nutrients. 14, 300, 2022.

Pence J, Morris R, Pischel I, Bloomer RJ. Assessment of Delphinol® on measures of vascular function in men and women. Journal of Food & Nutritional Sciences. 3(2): 18-30, 2021.

Bloomer RJ, Butawan M, Pigg B and Martin KR. Acute ingestion of a novel nitrate-rich dietary supplement significantly increases plasma nitrate/nitrite in physically active men and women. Nutrients. 12(4): 1176, 2020.

Pence J & Bloomer RJ. Impact of Nuun electrolyte tablets on fluid balance in active men and women. Nutrients. 12: 3030, 2020.

Bloomer RJ, Butawan M, van der Merwe M. An assessment of the glyconutrient Ambrotose™ on immunity, gut health, and safety in men and women: a placebo-controlled, double-blind, randomized clinical trial. Nutrients. 12(1751): 1-16, 2020.

Bloomer RJ, Butawan M, Pence J. Acute impact of a single dose of Dynamine®, TeaCrineÒ, caffeine, or their combination on systemic hemodynamics and associated measures in men and women. Medical Research Archives. 8(4): 1-25, 2020.

Bloomer RJ, Butawan M, Yates CR, Lin L, & Ma D. Blood MSM concentrations following escalating dosages of oral MSM in men and women. Journal of Nutrition and Food Sciences. 9(1): 1-5, 2019.

Wong T, Benjamin R, Bloomer RJ, & Buddington R. Small intestinal absorption of methylsulfonylmethane (MSM) and accumulation of the sulfur moiety in selected tissues of mice. Nutrients. 10(19): 1-9, 2018.

Melcher DA, Lee SR, Peel SA, Paquette MR, & Bloomer RJ. Effects of MSM supplementation on oxidative stress, muscle soreness, and performance variables following eccentric exercise. Gazzetta Medica Italiana - Archivio per le Scienze Mediche. 176(5): 271-283, 2017.

He H, Ma D, Crone LB, Butawan M, Meibohm B, Bloomer RJ, & Yates CR. Assessment of the drug-drug interaction potential between theacrine and caffeine in humans. Journal of Caffeine Research. 7(3): 95-102, 2017.

Bloomer RJ, MacDonnchadh JJ, Moran RG, Timmcke JQ, & Qin B. Impact of a dietary supplement containing Rosemary and Daylily on biochemical markers of cognitive health, sleep quality and related variables in men and women with insomnia. Health. 8: 1307-1322, 2016.

Moran RG, VonSchulze AT, & Bloomer RJ. Impact of an herbal dietary supplement containing Spilanthes acmella and Orchis latifolia on testosterone in young men: A pilot study. Journal of Biology and Life Science. 8(1): 28-41, 2016.

van der Merwe M, & Bloomer RJ. The influence of methylsulfonylmethane on inflammation-associated cytokine release before and following strenuous exercise. Journal of Sports Medicine. Volume 2016, Article ID 7498359: 1-9, 2016.

Bloomer RJ, Moran R, MacDonnchadh J, Lee SR, & Farber M. Impact of 2-nitrooxy-ethyl-2-amino-3-methylbutanoate on blood pressure and plasma nitrate/nitrite following acute exercise in normotensive men. Medical Research Archives. 3(6), 1-13, 2016.

Bloomer RJ, Melcher DA, & Benjamin R. Serum MSM concentrations following one month of MSM treatment in healthy men. Clinical Pharmacology & Biopharmaceutics. 4: 135, 2015.

Bloomer RJ, Schriefer JM, & Gunnels TA. Clinical safety assessment of oral higenamine supplementation in healthy young men. Human and Experimental Toxicology. January 14, 2015, doi: 10.1177/0960327114565490

Kuhman DJ, Joyner KJ, & Bloomer RJ. Cognitive performance and subjective mood following ingestion of a theacrine-containing multi-ingredient dietary supplement, caffeine, or placebo by healthy young men and women. Nutrients. 7, 9618-9632, 2015.